Year: 0 | Month: June | Volume 13 | Issue 3
Pharmacokinetic Evaluation of Marbofloxacin Following Single and Repetitive Intravenous Administration in Rabbits
Asif Majeed Mir1
Nitesh Kumar1
Arpita Shrivastav1
Rajeev Ranjan
Swatantra Kumar Singh
Alok Yadav
Neeraj Shrivastava
Sheikh
T.J
DOI:10.30954/2277-940X.03.2023.16
Abstract:
Pharmacokinetic study of marbofloxacin was carried out in rabbits following single and repetitive intravenous (IV) administration.
Serial blood samples were taken from days 1st and 5th of marbofloxacin administration. Concentrations of the marbofloxacin
in blood plasma were estimated by microbiological assay techniques. Various kinetic parameters were calculated by using
two compartment open model. Significantly higher plasma concentrations of the drug appeared from 0.5 to 12 hr on 5th day as
compared to 1st day of marbofloxacin administration. The minimum therapeutic concentration (≥ 0.25 µg/ml) of marbofloxacin
was maintained up to 12 hr in both 1st and 5th day of drug administration. Following multiple once IV dose, significantly higher
values of t1/2β, and AUC were observed in 5th day as compared to 1st day of marbofloxacin administration, whereas significantly
lower value of Vdarea and ClB were observed in 5th day as compared to 1st day of marbofloxacin administration. All the other
kinetic parameters differ non-significantly between 1st and 5th day of marbofloxacin administration. On the basis of present
findings a satisfactory dosage regimen of marbofloxacin @ 0.91±0.03 mg/kg bwt followed by 0.71±0.03 mg/kg bwt at 12 hr
intervals can be recommended to maintain the minimum therapeutic concentration (≥ 0.25 µg/ml)) during the treatment of
microbial infections in rabbit.
Highlights
- Significantly higher plasma concentrations of the marbofloxacin appeared from 0.5 to 12 hr on 5th day as compared to 1st day of drug administration.
- The minimum therapeutic concentration of marbofloxacin was maintained up to 12 hr in both 1st and 5th day of drug administration.
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